Ontology highlight
ABSTRACT:
SUBMITTER: Bates CA
PROVIDER: S-EPMC3535496 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Bates Caleb A CA Pomerantz William C WC Mapp Anna K AK
Biopolymers 20110101 1
Previously it was demonstrated that amphipathic isoxazolidines are able to functionally replace the transcriptional activation domains of endogenous transcriptional activators. In addition, in vitro binding studies suggested that a key binding partner of these molecules is the CREB Binding Protein (CBP), more specifically the KIX domain within this protein. Here we show that CBP plays an essential role in the ability of isoxazolidine transcriptional activation domains to activate transcription i ...[more]