Ontology highlight
ABSTRACT:
SUBMITTER: Breen ME
PROVIDER: S-EPMC7469456 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Breen Meghan E ME Mapp Anna K AK
Current opinion in chemical biology 20180717
Dysregulation of transcription is found in nearly every human disease, and as a result there has been intense interest in developing new therapeutics that target regulators of transcription. CREB binding protein (CBP) and its paralogue p300 are attractive targets due to their function as `master coactivators'. Although inhibitors of several CBP/p300 domains have been identified, the selectivity of many of these compounds has remained underexplored. Here, we review recent successes in the develop ...[more]