Ontology highlight
ABSTRACT:
SUBMITTER: Figueiredo AC
PROVIDER: S-EPMC3535606 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Figueiredo Ana C AC de Sanctis Daniele D Gutiérrez-Gallego Ricardo R Cereija Tatiana B TB Macedo-Ribeiro Sandra S Fuentes-Prior Pablo P Pereira Pedro José Barbosa PJ
Proceedings of the National Academy of Sciences of the United States of America 20121205 52
Anopheles mosquitoes are vectors of malaria, a potentially fatal blood disease affecting half a billion humans worldwide. These blood-feeding insects include in their antihemostatic arsenal a potent thrombin inhibitor, the flexible and cysteine-less anophelin. Here, we present a thorough structure-and-function analysis of thrombin inhibition by anophelin, including the 2.3-Å crystal structure of the human thrombin·anophelin complex. Anophelin residues 32-61 are well-defined by electron density, ...[more]