Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.
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ABSTRACT:
SUBMITTER: Sangal V
PROVIDER: S-EPMC3536230 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
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Global phylogeny of Shigella sonnei strains from limited single nucleotide polymorphisms (SNPs) and development of a rapid and cost-effective SNP-typing scheme for strain identification by high-resolution melting analysis.
Sangal Vartul V Holt Kathryn E KE Yuan Jianfeng J Brown Derek J DJ Filliol-Toutain Ingrid I Weill François-Xavier FX Kim Dong-Wook DW da Silveira Wanderley Dias WD Pickard Derek D Thomson Nicholas R NR Parkhill Julian J Yu Jun J
Journal of clinical microbiology 20121031 1
The current Shigella sonnei pandemic involves geographically associated, multidrug-resistant clones. This study has demonstrated that S. sonnei phylogeny can be accurately defined with limited single nucleotide polymorphisms (SNPs). By typing 6 informative SNPs using a high-resolution melting (HRM) assay, major S. sonnei lineages/sublineages can be identified as defined by whole-genome variation. ...[more]
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