Ontology highlight
ABSTRACT:
SUBMITTER: Coornaert A
PROVIDER: S-EPMC3536696 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Coornaert Audrey A Chiaruttini Claude C Springer Mathias M Guillier Maude M
PLoS genetics 20130103 1
PhoQ/PhoP is a central two-component system involved in magnesium homeostasis, pathogenicity, cell envelope composition, and acid resistance in several bacterial species. The small RNA GcvB is identified here as a novel direct regulator of the synthesis of PhoQ/PhoP in Escherichia coli, and this control relies on a novel pairing region of GcvB. After MicA, this is the second Hfq-dependent small RNA that represses expression of the phoPQ operon. Both MicA and GcvB bind phoPQ mRNA in vivo and in v ...[more]