Ontology highlight
ABSTRACT:
SUBMITTER: Miller SI
PROVIDER: S-EPMC297555 | biostudies-other | 1989 Jul
REPOSITORIES: biostudies-other
Miller S I SI Kukral A M AM Mekalanos J J JJ
Proceedings of the National Academy of Sciences of the United States of America 19890701 13
We have determined that Salmonella typhimurium strains with mutations in the positive regulatory locus phoP are markedly attenuated in virulence for BALB/c mice. The DNA sequence for the phoP locus indicates that it is composed of two genes present in an operon, termed phoP and phoQ. The deduced amino acid sequence of the phoP and phoQ gene products are highly similar to other members of bacterial two-component transcriptional regulators that respond to environmental stimuli. S. typhimurium stra ...[more]