Ontology highlight
ABSTRACT:
SUBMITTER: Sutton TA
PROVIDER: S-EPMC3537213 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Sutton Timothy A TA Hato Takashi T Mai Erik E Yoshimoto Momoko M Kuehl Sarah S Anderson Melissa M Mang Henry H Plotkin Zoya Z Chan Rebecca J RJ Dagher Pierre C PC
Journal of the American Society of Nephrology : JASN 20121206 1
In the rat, p53 promotes tubular apoptosis after ischemic AKI. Acute pharmacologic inhibition of p53 is protective in this setting, but chronic inhibition enhances fibrosis, demonstrating that the role of p53 in ischemic AKI is incompletely understood. Here, we investigated whether genetic absence of p53 is also protective in ischemic AKI. Surprisingly, p53-knockout mice (p53(-/-)) had worse kidney injury, compared with wild-type mice, and exhibited increased and prolonged infiltration of leukoc ...[more]