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Effect of vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana: a secondary analysis from the ObaapaVitA trial.


ABSTRACT: To determine the effect of weekly low-dose vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana.A cluster-randomized, triple-blind, placebo-controlled trial was conducted in seven districts of the Brong Ahafo region of Ghana. Women aged 15-45 years who were capable of giving informed consent and intended to live in the trial area for at least 3 months were enrolled and randomly assigned, according to their cluster of residence, to receive oral vitamin A (7500 ?g) or placebo once a week. Randomization was blocked, with two clusters in each fieldwork area allocated to vitamin A and two to placebo. Every 4 weeks, fieldworkers distributed capsules and collected data during home visits. Verbal autopsies were conducted by field supervisors and reviewed by physicians, who assigned a cause of death. Cause-specific mortality rates in both arms were compared by means of random-effects Poisson regression models to allow for the cluster randomization. Analysis was by intention-to-treat, based on cluster of residence, with women eligible for inclusion once they had consistently received the supplement or placebo capsules for 6 months.The analysis was based on 581?870 woman-years and 2624 deaths. Cause-specific mortality rates were found to be similar in the two study arms.Low-dose vitamin A supplements administered weekly are of no benefit in programmes to reduce mortality in women of childbearing age.

SUBMITTER: Hurt L 

PROVIDER: S-EPMC3537244 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Effect of vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana: a secondary analysis from the ObaapaVitA trial.

Hurt Lisa L   ten Asbroek Augustinus A   Amenga-Etego Seeba S   Zandoh Charles C   Danso Samuel S   Edmond Karen K   Hurt Chris C   Tawiah Charlotte C   Hill Zelee Z   Fenty Justin J   Owusu-Agyei Seth S   Campbell Oona M OM   Kirkwood Betty R BR  

Bulletin of the World Health Organization 20121031 1


<h4>Objective</h4>To determine the effect of weekly low-dose vitamin A supplementation on cause-specific mortality in women of reproductive age in Ghana.<h4>Methods</h4>A cluster-randomized, triple-blind, placebo-controlled trial was conducted in seven districts of the Brong Ahafo region of Ghana. Women aged 15-45 years who were capable of giving informed consent and intended to live in the trial area for at least 3 months were enrolled and randomly assigned, according to their cluster of reside  ...[more]

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