Ontology highlight
ABSTRACT:
SUBMITTER: Guo CJ
PROVIDER: S-EPMC3538129 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Guo Chun-Jun CJ Knox Benjamin P BP Chiang Yi-Ming YM Lo Hsien-Chun HC Sanchez James F JF Lee Kuan-Han KH Oakley Berl R BR Bruno Kenneth S KS Wang Clay C C CC
Organic letters 20121101 22
Meroterpenoids are natural products produced from polyketide and terpenoid precursors. A gene targeting system for A. terreus NIH2624 was developed, and a gene cluster for terretonin biosynthesis was characterized. The intermediates and shunt products were isolated from the mutant strains, and a pathway for terretonin biosynthesis is proposed. Analysis of two meroterpenoid pathways corresponding to terretonin in A. terreus and austinol in A. nidulans reveals that they are closely related evoluti ...[more]