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Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.

ABSTRACT: Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid.

SUBMITTER: Guo CJ

PROVIDER: S-EPMC4201328 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature

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Molecular genetic characterization of terreic acid pathway in Aspergillus terreus.

Guo Chun-Jun CJ Sun Wei-Wen WW Bruno Kenneth S KS Wang Clay C C CC

Organic letters 20140929 20

Terreic acid is a natural product derived from 6-methylsalicylic acid (6-MSA). A compact gene cluster for its biosynthesis was characterized. Isolation of the intermediates and shunt products from the mutant strains, combined with bioinformatic analyses, allowed for the proposition of a biosynthetic pathway for terreic acid. ...[more]

PMID: 25265334

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