Ontology highlight
ABSTRACT:
SUBMITTER: Ciesielska A
PROVIDER: S-EPMC3538301 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Ciesielska Agnieszka A Hadaczek Piotr P Mittermeyer Gabriele G Zhou Shangzhen S Wright J Fraser JF Bankiewicz Krystof S KS Forsayeth John J
Molecular therapy : the journal of the American Society of Gene Therapy 20120828 1
There is considerable interest in the use of adeno-associated virus serotype 9 (AAV9) for neurological gene therapy partly because of its ability to cross the blood-brain barrier to transduce astrocytes and neurons. This raises the possibility that AAV9 might also transduce antigen-presenting cells (APC) in the brain and provoke an adaptive immune response. We tested this hypothesis by infusing AAV9 vectors encoding foreign antigens, namely human aromatic L-amino acid decarboxylase (hAADC) and g ...[more]