Noninvasive in vivo imaging of pancreatic islet cell biology.
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ABSTRACT:
SUBMITTER: Speier S
PROVIDER: S-EPMC3538807 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Publications
Noninvasive in vivo imaging of pancreatic islet cell biology.
Speier Stephan S Nyqvist Daniel D Cabrera Over O Yu Jia J Molano R Damaris RD Pileggi Antonello A Moede Tilo T Köhler Martin M Wilbertz Johannes J Leibiger Barbara B Ricordi Camillo C Leibiger Ingo B IB Caicedo Alejandro A Berggren Per-Olof PO
Nature medicine 20080307 5
Advanced imaging techniques have become a valuable tool in the study of complex biological processes at the cellular level in biomedical research. Here, we introduce a new technical platform for noninvasive in vivo fluorescence imaging of pancreatic islets using the anterior chamber of the eye as a natural body window. Islets transplanted into the mouse eye engrafted on the iris, became vascularized, retained cellular composition, responded to stimulation and reverted diabetes. Laser-scanning mi ...[more]
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