Ontology highlight
ABSTRACT:
SUBMITTER: Gaglia JL
PROVIDER: S-EPMC3007157 | biostudies-literature | 2011 Jan
REPOSITORIES: biostudies-literature
Gaglia Jason L JL Guimaraes Alexander R AR Harisinghani Mukesh M Turvey Stuart E SE Jackson Richard R Benoist Christophe C Mathis Diane D Weissleder Ralph R
The Journal of clinical investigation 20101201 1
Type 1A diabetes (T1D) is an autoimmune disease characterized by leukocyte infiltration of the pancreatic islets of Langerhans. A major impediment to advances in understanding, preventing, and curing T1D has been the inability to "see" the disease initiate, progress, or regress, especially during the occult phase. Here, we report the development of a noninvasive method to visualize T1D at the target organ level in patients with active insulitis. Specifically, we visualized islet inflammation, ma ...[more]