Ontology highlight
ABSTRACT:
SUBMITTER: Dreyfus C
PROVIDER: S-EPMC3538841 | biostudies-literature | 2012 Sep
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20120809 6100
Identification of broadly neutralizing antibodies against influenza A viruses has raised hopes for the development of monoclonal antibody-based immunotherapy and "universal" vaccines for influenza. However, a substantial part of the annual flu burden is caused by two cocirculating, antigenically distinct lineages of influenza B viruses. Here, we report human monoclonal antibodies, CR8033, CR8071, and CR9114, that protect mice against lethal challenge from both lineages. Antibodies CR8033 and CR8 ...[more]