Ontology highlight
ABSTRACT:
SUBMITTER: Nanjunda R
PROVIDER: S-EPMC3539175 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Nanjunda Rupesh R Wilson W David WD
Current protocols in nucleic acid chemistry 20121201
Compounds that bind in the DNA minor groove have provided critical information on DNA molecular recognition, have found extensive uses in biotechnology, and are providing clinically useful drugs against diseases as diverse as cancer and sleeping sickness. This review focuses on the development of clinically useful heterocyclic diamidine minor groove binders. These compounds have shown us that the classical model for minor groove binding in AT DNA sequences must be expanded in several ways: compo ...[more]