Ontology highlight
ABSTRACT:
SUBMITTER: Hudson WH
PROVIDER: S-EPMC3539207 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Hudson William H WH Youn Christine C Ortlund Eric A EA
Nature structural & molecular biology 20121209 1
A newly discovered negative glucocorticoid response element (nGRE) mediates DNA-dependent transrepression by the glucocorticoid receptor (GR) across the genome and has a major role in immunosuppressive therapy. The nGRE differs dramatically from activating response elements, and the mechanism driving GR binding and transrepression is unknown. To unravel the mechanism of nGRE-mediated transrepression by the GR, we characterized the interaction between GR and an nGRE in the thymic stromal lymphopo ...[more]