Ontology highlight
ABSTRACT:
SUBMITTER: Levy JM
PROVIDER: S-EPMC3539744 | biostudies-literature | 2011 Jul
REPOSITORIES: biostudies-literature
Levy Jean M Mulcahy JM Thorburn Andrew A
Pharmacology & therapeutics 20110323 1
Autophagy is a catabolic process that turns over long-lived proteins and organelles and contributes to cell and organism survival in times of stress. Current cancer therapies including chemotherapy and radiation are known to induce autophagy within tumor cells. This is therefore an attractive process to target during cancer therapy as there are safe, clinically available drugs known to both inhibit and stimulate autophagy. However, there are conflicting positive and negative effects of autophagy ...[more]