Ontology highlight
ABSTRACT:
SUBMITTER: Mestre O
PROVIDER: S-EPMC3540035 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Mestre Olga O Hurtado-Ortiz Raquel R Dos Vultos Tiago T Namouchi Amine A Cimino Mena M Pimentel Madalena M Neyrolles Olivier O Gicquel Brigitte B
PloS one 20130108 1
Mycobacterium tuberculosis has the remarkable capacity to survive within the hostile environment of the macrophage, and to resist potent antibacterial molecules such as reactive oxygen species (ROS). Thus, understanding mycobacterial resistance mechanisms against ROS may contribute to the development of new anti-tuberculosis therapies. Here we identified genes involved in such mechanisms by screening a high-density transposon mutant library, and we show that several of them are involved in the i ...[more]