Ontology highlight
ABSTRACT:
SUBMITTER: Terman DS
PROVIDER: S-EPMC3541382 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Terman David S DS Viglianti Benjamin L BL Zennadi Rahima R Fels Diane D Boruta Richard J RJ Yuan Hong H Dreher Mathew R MR Grant Gerald G Rabbani Zahid N ZN Moon Ejung E Lan Lan L Eble Joseph J Cao Yiting Y Sorg Brian B Ashcraft Kathleen K Palmer Greg G Telen Marilyn J MJ Dewhirst Mark W MW
PloS one 20130109 1
Resistance of hypoxic solid tumor niches to chemotherapy and radiotherapy remains a major scientific challenge that calls for conceptually new approaches. Here we exploit a hitherto unrecognized ability of sickled erythrocytes (SSRBCs) but not normal RBCs (NLRBCs) to selectively target hypoxic tumor vascular microenviroment and induce diffuse vaso-occlusion. Within minutes after injection SSRBCs, but not NLRBCs, home and adhere to hypoxic 4T1 tumor vasculature with hemoglobin saturation levels a ...[more]