Ontology highlight
ABSTRACT:
SUBMITTER: Cyrklaff M
PROVIDER: S-EPMC5105170 | biostudies-literature | 2016 Nov
REPOSITORIES: biostudies-literature
Cyrklaff Marek M Srismith Sirikamol S Nyboer Britta B Burda Kvetoslava K Hoffmann Angelika A Lasitschka Felix F Adjalley Sophie S Bisseye Cyrille C Simpore Jacques J Mueller Ann-Kristin AK Sanchez Cecilia P CP Frischknecht Friedrich F Lanzer Michael M
Nature communications 20161108
Plasmodium falciparum infections can cause severe malaria, but not every infected person develops life-threatening complications. In particular, carriers of the structural haemoglobinopathies S and C and infants are protected from severe disease. Protection is associated with impaired parasite-induced host actin reorganization, required for vesicular trafficking of parasite-encoded adhesins, and reduced cytoadherence of parasitized erythrocytes in the microvasculature. Here we show that aberrant ...[more]