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Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin.


ABSTRACT: As discussed in the larger review in this special issue (MacDonald and Feifel), intranasal oxytocin (OT) is demonstrating a growing potential as a therapeutic agent in psychiatry. Importantly, research suggests that a variety of individual factors may influence a person's response to OT. In this mini-review, I provide a review of three: (1) sex and hormonal status; (2) genetic variation in aspects of the OT system (i.e., OT receptors); and (3) attachment history. Each of these factors will be important to monitor as we strive to develop a richer understanding of OT's role in human development, brain-based disease, and the potential for individualized, OT-targeted treatments.

SUBMITTER: Macdonald KS 

PROVIDER: S-EPMC3541513 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature

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Sex, receptors, and attachment: a review of individual factors influencing response to oxytocin.

Macdonald Kai S KS  

Frontiers in neuroscience 20130110


As discussed in the larger review in this special issue (MacDonald and Feifel), intranasal oxytocin (OT) is demonstrating a growing potential as a therapeutic agent in psychiatry. Importantly, research suggests that a variety of individual factors may influence a person's response to OT. In this mini-review, I provide a review of three: (1) sex and hormonal status; (2) genetic variation in aspects of the OT system (i.e., OT receptors); and (3) attachment history. Each of these factors will be im  ...[more]

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