Ontology highlight
ABSTRACT:
SUBMITTER: Lo Sardo A
PROVIDER: S-EPMC3542376 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Lo Sardo Alessandra A Altamura Sandro S Pegoraro Silvia S Maurizio Elisa E Sgarra Riccardo R Manfioletti Guidalberto G
PloS one 20130110 1
PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. Only few substrates of this enzyme are known and therefore its cellular role is not well understood. To identify in an unbiased manner substrates and potential regulators of PRMT6 we have used a yeast two-hybrid approach. We identified 36 new putative partners for PRMT6 and we validated the interaction in vivo for 7 of them. In addition, ...[more]