Ontology highlight
ABSTRACT:
SUBMITTER: Veland N
PROVIDER: S-EPMC5753604 | biostudies-literature | 2017 Dec
REPOSITORIES: biostudies-literature
Veland Nicolas N Hardikar Swanand S Zhong Yi Y Gayatri Sitaram S Dan Jiameng J Strahl Brian D BD Rothbart Scott B SB Bedford Mark T MT Chen Taiping T
Cell reports 20171201 12
DNA methylation plays crucial roles in chromatin structure and gene expression. Aberrant DNA methylation patterns, including global hypomethylation and regional hypermethylation, are associated with cancer and implicated in oncogenic events. How DNA methylation is regulated in developmental and cellular processes and dysregulated in cancer is poorly understood. Here, we show that PRMT6, a protein arginine methyltransferase responsible for asymmetric dimethylation of histone H3 arginine 2 (H3R2me ...[more]