Ontology highlight
ABSTRACT:
SUBMITTER: Lampert F
PROVIDER: S-EPMC3542791 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Lampert Fabienne F Mieck Christine C Alushin Gregory M GM Nogales Eva E Westermann Stefan S
The Journal of cell biology 20121231 1
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce microtubule dynamics into chromosome movement. In budding yeast, the kinetochore-microtubule interface is formed by the plus end-associated Dam1 complex and the kinetochore-resident Ndc80 complex, but how they work in combination and whether a physical association between them is critical for chromosome segregation is poorly understood. Here, we define structural elements required for the Ndc80-Dam1 ...[more]