Ontology highlight
ABSTRACT:
SUBMITTER: Jenni S
PROVIDER: S-EPMC6815591 | biostudies-literature | 2018 May
REPOSITORIES: biostudies-literature
Jenni Simon S Harrison Stephen C SC
Science (New York, N.Y.) 20180501 6388
Kinetochores connect mitotic-spindle microtubules with chromosomes, allowing microtubule depolymerization to pull chromosomes apart during anaphase while resisting detachment as the microtubule shortens. The heterodecameric DASH/Dam1 complex (DASH/Dam1c), an essential component of yeast kinetochores, assembles into a microtubule-encircling ring. The ring associates with rodlike Ndc80 complexes to organize the kinetochore-microtubule interface. We report the cryo-electron microscopy structure (at ...[more]