Ontology highlight
ABSTRACT:
SUBMITTER: Babrzadeh F
PROVIDER: S-EPMC3543120 | biostudies-literature | 2013 Feb
REPOSITORIES: biostudies-literature
Babrzadeh Farbod F Varghese Vici V Pacold Mary M Liu Tommy F TF Nyrén Pål P Schiffer Celia C Fessel W Jeffrey WJ Shafer Robert W RW
The Journal of antimicrobial chemotherapy 20121019 2
<h4>Objectives</h4>To determine whether pan-protease inhibitor (PI)-resistant virus populations are composed predominantly of viruses with resistance to all PIs or of diverse virus populations with resistance to different subsets of PIs.<h4>Methods</h4>We performed deep sequencing of plasma virus samples from nine patients with high-level genotypic and/or phenotypic resistance to all licensed PIs. The nine virus samples had a median of 12 PI resistance mutations by direct PCR Sanger sequencing.< ...[more]