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Nuclear hormone receptors in podocytes.


ABSTRACT: Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the progress of our understanding of the role of nuclear receptors and their ligands in kidney physiology with emphasis on their roles in treating glomerular disorders and podocyte injury repair responses.

SUBMITTER: Khurana S 

PROVIDER: S-EPMC3543367 | biostudies-literature | 2012 Sep

REPOSITORIES: biostudies-literature

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Nuclear hormone receptors in podocytes.

Khurana Simran S   Bruggeman Leslie A LA   Kao Hung-Ying HY  

Cell & bioscience 20120920 1


Nuclear receptors are a family of ligand-activated, DNA sequence-specific transcription factors that regulate various aspects of animal development, cell proliferation, differentiation, and homeostasis. The physiological roles of nuclear receptors and their ligands have been intensively studied in cancer and metabolic syndrome. However, their role in kidney diseases is still evolving, despite their ligands being used clinically to treat renal diseases for decades. This review will discuss the pr  ...[more]

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