HIV-1 Nef in macrophage-mediated disease pathogenesis.
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ABSTRACT:
SUBMITTER: Lamers SL
PROVIDER: S-EPMC3544535 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Publications
HIV-1 Nef in macrophage-mediated disease pathogenesis.
Lamers Susanna L SL Fogel Gary B GB Singer Elyse J EJ Salemi Marco M Nolan David J DJ Huysentruyt Leanne C LC McGrath Michael S MS
International reviews of immunology 20121201 6
Combined anti-retroviral therapy (cART) has significantly reduced the number of AIDS-associated illnesses and changed the course of HIV-1 disease in developed countries. Despite the ability of cART to maintain high CD4+ T-cell counts, a number of macrophage-mediated diseases can still occur in HIV-infected subjects. These diseases include lymphoma, metabolic diseases, and HIV-associated neurological disorders. Within macrophages, the HIV-1 regulatory protein "Nef" can modulate surface receptors, ...[more]
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