Unknown

Dataset Information

0

Nef-mediated inhibition of NFAT following TCR stimulation differs between HIV-1 subtypes.


ABSTRACT: Functional characterisation of different HIV-1 subtypes may improve understanding of viral pathogenesis and spread. Here, we evaluated the ability of 345 unique HIV-1 Nef clones representing subtypes A, B, C and D to inhibit NFAT signalling following TCR stimulation. The contribution of this Nef function to disease progression was also assessed in 211 additional Nef clones isolated from unique subtype C infected individuals in early or chronic infection. On average, subtype A and C Nef clones exhibited significantly lower ability to inhibit TCR-mediated NFAT signalling compared to subtype B and D Nef clones. While this observation corroborates accumulating evidence supporting relative attenuation of subtypes A and C that may paradoxically contribute to their increased global prevalence and spread, no significant correlations between Nef-mediated NFAT inhibition activity and clinical markers of HIV-1 infection were observed, indicating that the relationship between Nef function and pathogenesis is complex.

SUBMITTER: Naidoo L 

PROVIDER: S-EPMC6526282 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC3849644 | biostudies-literature
| S-EPMC7052273 | biostudies-literature
| S-EPMC6431140 | biostudies-literature
| S-EPMC3544535 | biostudies-literature
| S-EPMC3347365 | biostudies-literature
| S-EPMC2783173 | biostudies-literature
| S-EPMC4660847 | biostudies-literature
| S-EPMC4429734 | biostudies-literature
| S-EPMC5386374 | biostudies-literature
| S-EPMC3358010 | biostudies-literature