Ontology highlight
ABSTRACT:
SUBMITTER: Lapouge G
PROVIDER: S-EPMC3545290 | biostudies-literature | 2012 Dec
REPOSITORIES: biostudies-literature
Lapouge Gaëlle G Beck Benjamin B Nassar Dany D Dubois Christine C Dekoninck Sophie S Blanpain Cédric C
The EMBO journal 20121127 24
Cancer stem cells have been described in various cancers including squamous tumours of the skin by their ability to reform secondary tumours upon transplantation into immunodeficient mice. Here, we used transplantation of limiting dilution of different populations of FACS-isolated tumour cells from four distinct mouse models of squamous skin tumours to investigate the frequency of tumour propagating cells (TPCs) at different stages of tumour progression. We found that benign papillomas, despite ...[more]