Ontology highlight
ABSTRACT:
SUBMITTER: Nystrom S
PROVIDER: S-EPMC3545309 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Nyström Sanna S Antoine Daniel J DJ Lundbäck Peter P Lock John G JG Nita Andreia F AF Högstrand Kari K Grandien Alf A Erlandsson-Harris Helena H Andersson Ulf U Applequist Steven E SE
The EMBO journal 20121207 1
Infection of macrophages by bacterial pathogens can trigger Toll-like receptor (TLR) activation as well as Nod-like receptors (NLRs) leading to inflammasome formation and cell death dependent on caspase-1 (pyroptosis). Complicating the study of inflammasome activation is priming. Here, we develop a priming-free NLRC4 inflammasome activation system to address the necessity and role of priming in pyroptotic cell death and damage-associated molecular pattern (DAMP) release. We find pyroptosis is no ...[more]