Ontology highlight
ABSTRACT:
SUBMITTER: McKinney-Freeman S
PROVIDER: S-EPMC3545475 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Cell stem cell 20121101 5
Transcriptome analysis of adult hematopoietic stem cells (HSCs) and their progeny has revealed mechanisms of blood differentiation and leukemogenesis, but a similar analysis of HSC development is lacking. Here, we acquired the transcriptomes of developing HSCs purified from >2,500 murine embryos and adult mice. We found that embryonic hematopoietic elements clustered into three distinct transcriptional states characteristic of the definitive yolk sac, HSCs undergoing specification, and definitiv ...[more]