Ontology highlight
ABSTRACT:
SUBMITTER: Pellin D
PROVIDER: S-EPMC6546699 | biostudies-literature | 2019 Jun
REPOSITORIES: biostudies-literature
Nature communications 20190603 1
Hematopoietic Stem/Progenitor cells (HSPCs) are endowed with the role of maintaining a diverse pool of blood cells throughout the human life. Despite recent efforts, the nature of the early cell fate decisions remains contentious. Using single-cell RNA-Seq, we show that existing approaches to stratify bone marrow CD34+ cells reveal a hierarchically-structured transcriptional landscape of hematopoietic differentiation. Still, this landscape misses important early fate decisions. We here provide a ...[more]