Dataset Information

Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.

ABSTRACT: A single nucleotide polymorphism GRN rs5848 (3'UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson's disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold increased risk of PD (95% CI: 1.77?2.34, P?=?0.021). PD patients demonstrate a higher frequency of T allele (37.2%) than controls (32.2%; odds ratio [OR]?=?1.24, 95% CI: 1.04?1.49, P?=?0.017). This susceptibility was particularly observed in female subjects, in which TT genotype had a 2.16-fold increased risk of PD as compared with controls(95% CI: 1.24?3.78, P?=?0.006). The frequency of T allele (39.3%) in female PD patients was higher than in female control subjects (31.1%; OR?=?1.43, CI: 1.11?1.87, P?=?0.007). No association was observed between GRN rs5848 and susceptibility in male subjects. These findings show that the GRN rs5848 TT genotype and T allele are risk factors for female Taiwanese patients with PD.

SUBMITTER: Chang KH

PROVIDER: S-EPMC3546937 | biostudies-literature | 2013

REPOSITORIES: biostudies-literature

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Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.

Chang Kuo-Hsuan KH Chen Chiung-Mei CM Chen Yi-Chun YC Hsiao Ya-Chin YC Huang Chin-Chang CC Kuo Hung-Chou HC Hsu Hsuan-Chu HC Lee-Chen Guey-Jen GJ Wu Yih-Ru YR

PloS one 20130116 1

A single nucleotide polymorphism GRN rs5848 (3'UTR+78 C>T) was reported to alter the risk for frontotemporal lobar degeneration. Herein, we investigated the effect of GRN rs5848 on the risk of Parkinson's disease (PD) by genotyping 573 Taiwanese patients with PD and 490 age-matched control subjects. Compared to subjects with CC genotype, those with TT genotype had a 1.58-fold increased risk of PD (95% CI: 1.77∼2.34, P = 0.021). PD patients demonstrate a higher frequency of T allele (37.2%) than ...[more]

PMID: 23342160

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Dataset Information

Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.

Publications

Association between GRN rs5848 polymorphism and Parkinson's disease in Taiwanese population.

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