Ontology highlight
ABSTRACT:
SUBMITTER: Kong A
PROVIDER: S-EPMC3548427 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Kong Augustine A Frigge Michael L ML Masson Gisli G Besenbacher Soren S Sulem Patrick P Magnusson Gisli G Gudjonsson Sigurjon A SA Sigurdsson Asgeir A Jonasdottir Aslaug A Jonasdottir Adalbjorg A Wong Wendy S W WS Sigurdsson Gunnar G Walters G Bragi GB Steinberg Stacy S Helgason Hannes H Thorleifsson Gudmar G Gudbjartsson Daniel F DF Helgason Agnar A Magnusson Olafur Th OT Thorsteinsdottir Unnur U Stefansson Kari K
Nature 20120801 7412
Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage. We show that in our samples, with an average father's age of 29.7, the average de novo mutation rate is 1.20 × 10(-8) per nucleotide per generation. Most notably, the diversity in mutation rate of singl ...[more]