Ontology highlight
ABSTRACT:
SUBMITTER: Kong A
PROVIDER: S-EPMC3548427 | biostudies-literature | 2012 Aug
REPOSITORIES: biostudies-literature
Nature 20120801 7412
Mutations generate sequence diversity and provide a substrate for selection. The rate of de novo mutations is therefore of major importance to evolution. Here we conduct a study of genome-wide mutation rates by sequencing the entire genomes of 78 Icelandic parent-offspring trios at high coverage. We show that in our samples, with an average father's age of 29.7, the average de novo mutation rate is 1.20 × 10(-8) per nucleotide per generation. Most notably, the diversity in mutation rate of singl ...[more]