Ontology highlight
ABSTRACT:
SUBMITTER: Taylor JL
PROVIDER: S-EPMC6620346 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Taylor Jacob L JL Debost Jean-Christophe P G JPG Morton Sarah U SU Wigdor Emilie M EM Heyne Henrike O HO Lal Dennis D Howrigan Daniel P DP Bloemendal Alex A Larsen Janne T JT Kosmicki Jack A JA Weiner Daniel J DJ Homsy Jason J Seidman Jonathan G JG Seidman Christine E CE Agerbo Esben E McGrath John J JJ Mortensen Preben Bo PB Petersen Liselotte L Daly Mark J MJ Robinson Elise B EB
Nature communications 20190710 1
There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of risk from such mutations in the male germline is unknown. Quantifying this risk would clarify the clinical significance of delayed paternity. Using parent-child trio whole-exome-sequen ...[more]