Ontology highlight
ABSTRACT:
SUBMITTER: Taylor JL
PROVIDER: S-EPMC6620346 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Nature communications 20190710 1
There are established associations between advanced paternal age and offspring risk for psychiatric and developmental disorders. These are commonly attributed to genetic mutations, especially de novo single nucleotide variants (dnSNVs), that accumulate with increasing paternal age. However, the actual magnitude of risk from such mutations in the male germline is unknown. Quantifying this risk would clarify the clinical significance of delayed paternity. Using parent-child trio whole-exome-sequen ...[more]