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Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.

ABSTRACT: Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7(+) naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4(+) T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cell zone by a mechanism dependent on the chemokine CXCL13, B cells and lymphotoxin. Notably, lymphotoxin-expressing B cells, CXCR5-expressing DCs and T cells, and CXCL13 were also necessary for development of interleukin 4 (IL-4)-producing type 2 helper T cells (T(H)2 cells), which suggests that T(H)2 differentiation can initiate outside the T cell zone.

SUBMITTER: Leon B

PROVIDER: S-EPMC3548431 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Regulation of T(H)2 development by CXCR5+ dendritic cells and lymphotoxin-expressing B cells.

León Beatriz B Ballesteros-Tato André A Browning Jeffrey L JL Dunn Robert R Randall Troy D TD Lund Frances E FE

Nature immunology 20120527 7

Although cognate encounters between antigen-bearing dendritic cells (DCs) that express the chemokine receptor CCR7 and CCR7(+) naive T cells take place in the T cell zone of lymph nodes, it is unknown whether the colocalization of DCs and T cells in the T cell area is required for the generation of effector cells. Here we found that after infection with an intestinal nematode, antigen-bearing DCs and CD4(+) T cells upregulated the chemokine receptor CXCR5 and localized together outside the T cel ...[more]

PMID: 22634865

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