Ontology highlight
ABSTRACT:
SUBMITTER: Keshari KR
PROVIDER: S-EPMC3548990 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Keshari Kayvan R KR Sriram Renuka R Koelsch Bertram L BL Van Criekinge Mark M Wilson David M DM Kurhanewicz John J Wang Zhen J ZJ
Cancer research 20121130 2
Renal cell carcinomas (RCC) are a heterogeneous group of tumors with a wide range of aggressiveness. Noninvasive methods to confidently predict the tumor biologic behavior and select appropriate treatment are lacking. Here, we investigate the dynamic metabolic flux in living RCC cells using hyperpolarized (13)C-pyruvate magnetic resonance spectroscopy (MRS) combined with a bioreactor platform and interrogated the biochemical basis of the MRS data with respect to cancer aggressiveness. RCC cells ...[more]