Ontology highlight
ABSTRACT:
SUBMITTER: Mertz AF
PROVIDER: S-EPMC3549115 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Mertz Aaron F AF Che Yonglu Y Banerjee Shiladitya S Banerjee Shiladitya S Goldstein Jill M JM Rosowski Kathryn A KA Revilla Stephen F SF Niessen Carien M CM Marchetti M Cristina MC Dufresne Eric R ER Horsley Valerie V
Proceedings of the National Academy of Sciences of the United States of America 20121231 3
Cell-cell and cell-matrix adhesions play essential roles in the function of tissues. There is growing evidence for the importance of cross talk between these two adhesion types, yet little is known about the impact of these interactions on the mechanical coupling of cells to the extracellular matrix (ECM). Here, we combine experiment and theory to reveal how intercellular adhesions modulate forces transmitted to the ECM. In the absence of cadherin-based adhesions, primary mouse keratinocytes wit ...[more]