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Multiple choices for HIV therapy with integrase strand transfer inhibitors.

ABSTRACT: Two integrases inhibitors, raltegravir and elvitegravir, have now been approved by regulatory agencies for use in the treatment of HIV-infected patients; and the approval of a third such drug, dolutegravir, is expected during 2013 on the basis of several phase 3 clinical trials. The advent of this new class of antiretroviral (ARV) medications represents a major advance in the management of HIV infection, and each of these three drugs can be expected to continue to be an important component of ARV combination regimens.

SUBMITTER: Raffi F 

PROVIDER: S-EPMC3549750 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Multiple choices for HIV therapy with integrase strand transfer inhibitors.

Raffi Francois F   Wainberg Mark A MA  

Retrovirology 20121219

Two integrases inhibitors, raltegravir and elvitegravir, have now been approved by regulatory agencies for use in the treatment of HIV-infected patients; and the approval of a third such drug, dolutegravir, is expected during 2013 on the basis of several phase 3 clinical trials. The advent of this new class of antiretroviral (ARV) medications represents a major advance in the management of HIV infection, and each of these three drugs can be expected to continue to be an important component of AR  ...[more]

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