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Integrase Strand Transfer Inhibitors in HIV Therapy.


ABSTRACT: HIV drug resistance has been one of the major obstacles to HIV eradication and has contributed to the need for the constant development of new antiretroviral drugs over the past 25 years. With the recent approval of dolutegravir for human therapy by the U.S. Food and Drug Administration, health practitioners may soon have access to three integrase strand transfer inhibitors to treat individuals living with HIV. Here, we review the use of raltegravir, elvitegravir, and dolutegravir for use in first- and second-line HIV treatment regimens and the issue of HIV resistance against integrase inhibitors.

SUBMITTER: Mesplede T 

PROVIDER: S-EPMC4108112 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature

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Integrase Strand Transfer Inhibitors in HIV Therapy.

Mesplède Thibault T   Wainberg Mark A MA  

Infectious diseases and therapy 20131119 2


HIV drug resistance has been one of the major obstacles to HIV eradication and has contributed to the need for the constant development of new antiretroviral drugs over the past 25 years. With the recent approval of dolutegravir for human therapy by the U.S. Food and Drug Administration, health practitioners may soon have access to three integrase strand transfer inhibitors to treat individuals living with HIV. Here, we review the use of raltegravir, elvitegravir, and dolutegravir for use in fir  ...[more]

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