Ontology highlight
ABSTRACT:
SUBMITTER: Lyketsos CG
PROVIDER: S-EPMC3552463 | biostudies-literature | 2012 Nov
REPOSITORIES: biostudies-literature
Lyketsos Constantine G CG Targum Steven D SD Pendergrass Jo Cara JC Lozano Andres M AM
Innovations in clinical neuroscience 20121101 11-12
Recent studies have identified an association between memory deficits and defects of the integrated neuronal cortical areas known collectively as the default mode network. It is conceivable that the amyloid deposition or other molecular abnormalities seen in patients with Alzheimer's disease may interfere with this network and disrupt neuronal circuits beyond the localized brain areas. Therefore, Alzheimer's disease may be both a degenerative disease and a broader system-level disorder affecting ...[more]