A Phase II Study of Fornix Deep Brain Stimulation in Mild Alzheimer's Disease.

ABSTRACT:

Background

Deep brain stimulation (DBS) is used to modulate the activity of dysfunctional brain circuits. The safety and efficacy of DBS in dementia is unknown.

Objective

To assess DBS of memory circuits as a treatment for patients with mild Alzheimer's disease (AD).

Methods

We evaluated active "on" versus sham "off" bilateral DBS directed at the fornix-a major fiber bundle in the brain's memory circuit-in a randomized, double-blind trial (ClinicalTrials.gov NCT01608061) in 42 patients with mild AD. We measured cognitive function and cerebral glucose metabolism up to 12 months post-implantation.

Results

Surgery and electrical stimulation were safe and well tolerated. There were no significant differences in the primary cognitive outcomes (ADAS-Cog 13, CDR-SB) i

SUBMITTER: Lozano AM 

PROVIDER: S-EPMC5026133 | biostudies-literature | 2016 Sep

REPOSITORIES: biostudies-literature