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Late HIV diagnosis is a major risk factor for intensive care unit admission in HIV-positive patients: a single centre observational cohort study.


ABSTRACT:

Background

HIV positive patients are at risk of infectious and non-infectious complications that may necessitate intensive care unit (ICU) admission. While the characteristics of patients requiring ICU admission have been described previously, these studies did not include information on the denominator population from which these cases arose.

Methods

We conducted an observational cohort study of ICU admissions among 2751 HIV positive patients attending King's College Hospital, South London, UK. Poisson regression models were used to identify factors associated with ICU admission.

Results

The overall incidence rate of ICU admission was 1.0 [95% CI 0.8, 1.2] per 100 person-years of follow up, and particularly high early (during the first 3 months) following HIV diagnosis (12.4 [8.7, 17.3] per 100 person-years compared to 0.37 [0.27, 0.50] per 100 person-years thereafter; incidence rate ratio 33.5 [23.4, 48.1], p?ConclusionsLate HIV diagnosis was a major risk factor for early ICU admission in our cohort. Earlier HIV diagnosis allowing cART initiation at CD4 cell counts of 350 cells/mm3 is likely to have a significant impact on the need for ICU care.

SUBMITTER: Shrosbree J 

PROVIDER: S-EPMC3553027 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature

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Late HIV diagnosis is a major risk factor for intensive care unit admission in HIV-positive patients: a single centre observational cohort study.

Shrosbree Julia J   Campbell Lucy J LJ   Ibrahim Fowzia F   Hopkins Phillip P   Vizcaychipi Marcela M   Strachan Stephanie S   Post Frank A FA  

BMC infectious diseases 20130119


<h4>Background</h4>HIV positive patients are at risk of infectious and non-infectious complications that may necessitate intensive care unit (ICU) admission. While the characteristics of patients requiring ICU admission have been described previously, these studies did not include information on the denominator population from which these cases arose.<h4>Methods</h4>We conducted an observational cohort study of ICU admissions among 2751 HIV positive patients attending King's College Hospital, So  ...[more]

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