Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
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ABSTRACT:
SUBMITTER: Smith MR
PROVIDER: S-EPMC3553748 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Publications
Identification of gold nanoparticle-resistant mutants of Saccharomyces cerevisiae suggests a role for respiratory metabolism in mediating toxicity.
Smith Mark R MR Boenzli Matthew G MG Hindagolla Vihangi V Ding Jun J Miller John M JM Hutchison James E JE Greenwood Jeffrey A JA Abeliovich Hagai H Bakalinsky Alan T AT
Applied and environmental microbiology 20121109 2
Positively charged gold nanoparticles (0.8-nm core diameter) reduced yeast survival, but not growth, at a concentration of 10 to 100 μg/ml. Among 17 resistant deletion mutants isolated in a genome-wide screen, highly significant enrichment was observed for respiration-deficient mutants lacking genes encoding proteins associated with the mitochondrion. ...[more]
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