Ontology highlight
ABSTRACT:
SUBMITTER: Goller T
PROVIDER: S-EPMC3556029 | biostudies-literature | 2013
REPOSITORIES: biostudies-literature
Goller Tobias T Seibold Ursula K UK Kremmer Elisabeth E Voos Wolfgang W Kolanus Waldemar W
PloS one 20130125 1
The mitochondrial AAA+-ATPase ATAD3 is implicated in the regulation of mitochondrial and ER dynamics and was shown to be necessary for larval development in Caenorhabditis elegans. In order to elucidate the relevance of ATAD3 for mammalian development, the phenotype of an Atad3 deficient mouse line was analyzed. Atad3 deficient embryos die around embryonic day E7.5 due to growth retardation and a defective development of the trophoblast lineage immediately after implantation into the uterus. Thi ...[more]