Ontology highlight
ABSTRACT:
SUBMITTER: Cong L
PROVIDER: S-EPMC3556390 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Cong Le L Zhou Ruhong R Kuo Yu-Chi YC Cunniff Margaret M Zhang Feng F
Nature communications 20120724
Transcription activator-like effectors are sequence-specific DNA-binding proteins that harbour modular, repetitive DNA-binding domains. Transcription activator-like effectors have enabled the creation of customizable designer transcriptional factors and sequence-specific nucleases for genome engineering. Here we report two improvements of the transcription activator-like effector toolbox for achieving efficient activation and repression of endogenous gene expression in mammalian cells. We show t ...[more]