Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi K
PROVIDER: S-EPMC5428041 | biostudies-literature | 2017 Mar
REPOSITORIES: biostudies-literature
Takeuchi Koh K Imai Misaki M Shimada Ichio I
Scientific reports 20170321 1
LmrR is a multidrug binding transcriptional repressor that controls the expression of a major multidrug transporter, LmrCD, in Lactococcus lactis. Promiscuous compound ligations reduce the affinity of LmrR for the lmrCD operator by several fold to release the transcriptional repression; however, the affinity reduction is orders of magnitude smaller than that of typical transcriptional repressors. Here, we found that the transcriptional regulation of LmrR is achieved through an equilibrium betwee ...[more]