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Cell instructive microporous scaffolds through interface engineering.


ABSTRACT: The design of novel biomaterials for regenerative medicine requires incorporation of well-defined physical and chemical properties that mimic the native extracellular matrix (ECM). Here, we report the synthesis and characterization of porous foams prepared by high internal phase emulsion (HIPE) templating using amphiphilic copolymers that act as surfactants during the HIPE process. We combine different copolymers exploiting oil-water interface confined phase separation to engineer the surface topology of foam pores with nanoscopic domains of cell inert and active chemistries mimicking native matrix. We further demonstrate how proteins and hMSCs adhere in a domain specific manner.

SUBMITTER: Viswanathan P 

PROVIDER: S-EPMC3556732 | biostudies-literature | 2012 Dec

REPOSITORIES: biostudies-literature

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Cell instructive microporous scaffolds through interface engineering.

Viswanathan Priyalakshmi P   Chirasatitsin Somyot S   Ngamkham Kamolchanok K   Engler Adam J AJ   Battaglia Giuseppe G  

Journal of the American Chemical Society 20121130 49


The design of novel biomaterials for regenerative medicine requires incorporation of well-defined physical and chemical properties that mimic the native extracellular matrix (ECM). Here, we report the synthesis and characterization of porous foams prepared by high internal phase emulsion (HIPE) templating using amphiphilic copolymers that act as surfactants during the HIPE process. We combine different copolymers exploiting oil-water interface confined phase separation to engineer the surface to  ...[more]

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