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Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering.

ABSTRACT: A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media.

SUBMITTER: Caliari SR

PROVIDER: S-EPMC4409544 | biostudies-literature | 2015 Apr

REPOSITORIES: biostudies-literature

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Collagen Scaffolds Incorporating Coincident Gradations of Instructive Structural and Biochemical Cues for Osteotendinous Junction Engineering.

Caliari Steven R SR Weisgerber Daniel W DW Grier William K WK Mahmassani Ziad Z Boppart Marni D MD Harley Brendan A C BA

Advanced healthcare materials 20150119 6

A fully 3D biomaterial containing overlapping gradations of structural, compositional, and biomolecular cues as seen in native orthopedic interfaces is described for the first time. A multi-compartment collagen scaffold is created for engineering tendon-bone junctions connected by a continuous interface that can induce spatially specific MSC differentiation down tenogenic and osteogenic lineages without the use of differentiation media. ...[more]

PMID: 25597299

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